On May 20, 2021, Liu, Kun; Chen, Kennedy S.; Sen, Dipankar; Yu, Hua-Zhong published an article.Computed Properties of 143-10-2 The title of the article was Ultrasensitive detection of total copper with an electrochemical biosensor built on the in cis coupling of hexynyl CLICK-17 DNAzyme with azido self-assembled monolayers. And the article contained the following:
New methods to detect Cu sensitively and specifically are of practical importance because of its presence in both ecol. and biol. systems. Herein, the authors report a newly selected DNAzyme, CLICK-17, which catalyzes the azide-alkyne cycloaddition reaction strictly dependent on the presence of Cu, as a superior transducer for electrochem. Cu quantitation. CLICK-17 offers the following notable advantages: it does not require the presence of an unstable reducing agent (detects both Cu(II) and Cu(I) in samples); it offers rapid detection owing to the fast in cis coupling kinetics; and, it generates no background because its catalytic activity strictly relies on the presence of Cu (signal-on). For performing electrochem. sensing, the DNAzyme efficiently couples to a binary 11-azido-1-undecanethiolate/octanethiolate monolayer on Au (N3C11S-/C8S-Au), which is then accurately quantitated by the cyclic voltammetric response of electrostatically bound [Ru(NH3)6]3+. As the neg. charges on the phosphate backbone of surface-bound 79nt-DNA strands (CLICK-17) are inclusively compensated by the multiply charged redox cations (e.g., [Ru(NH3)6]3+) at low ionic strength, the electrochem. signal is naturally amplified (∼ 30 folds). Thus constructed biosensor detects Cu(II) with a LOD of 3.5 nM and Cu(I) with a LOD of 0.8 nM, which is also free of background signals and highly specific against other metal ions. More importantly, the authors showed the successful application of this DNAzyme-based electrochem. sensor to determine Cu concentrations in natural ores from the mining industry, with performance comparable to the Au standard flame at. absorption spectrophotometry. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Computed Properties of 143-10-2
The Article related to detection copper electrochem biosensor coupling hexynyl click17 dnazyme, azido self assembled monolayer sensor, Placeholder for records without volume info and other aspects.Computed Properties of 143-10-2
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