On August 31, 2012, Lee, Sang S.; Hong, Dong K.; Jeong, Nam J.; Lee, Jeung H.; Choi, Yun-Seok; Lee, Ai-Young; Lee, Cheol-Heon; Kim, Kea J.; Park, Hae Y.; Yang, Jun-Mo; Lee, Ga-Young; Lee, Joon; Eun, Hee C.; Moon, Kee-Chan; Seo, Seong J.; Hong, Chang K.; Lee, Sang W.; Choi, Hae Y.; Lee, Jun Y. published an article.Product Details of 4719-04-4 The title of the article was Multicenter study of preservative sensitivity in patients with suspected cosmetic contact dermatitis in Korea. And the article contained the following:
As many new cosmetic products are introduced into the market, attention must be given to contact dermatitis, which is commonly caused by cosmetics. We investigate the prevalence of preservative allergy in 584 patients with suspected cosmetic contact dermatitis at 11 different hospitals. From Jan. 2010 to March 2011, 584 patients at 11 hospital dermatol. departments presented with cosmetic contact dermatitis symptoms. These patients were patch-tested for preservative allergens. An irritancy patch test performed on 30 control subjects using allergens of various concentrations showed high irritancy rates. Preservative hypersensitivity was detected in 41.1% of patients. Allergens with the highest pos. test rates were benzalkonium chloride (12.1%), thimerosal (9.9%) and methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) (5.5%). Benzalkonium chloride and chlorphenesin had the highest irritancy rate based on an irritancy patch test performed using various concentrations Seven of 30 normal subjects had a pos. irritant patch reading with 0.1 % benzalkonium chloride and eight of 30 normal subjects had a pos. irritant patch reading at 4 days with 0.5% chlorphenesin in petrolatum. Although benzalkonium chloride was highly pos. for skin reactions in our study, most reactions were probably irritation. MCI/MI and thimerosal showed highly pos. allergy reactions in our study. The optimum concentration of chlorphenesin to avoid skin reactions is less than 0.5%. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Product Details of 4719-04-4
The Article related to cosmetic benzalkonium chloride merthiolate contact dermatitis preservative, Immunochemistry: Allergy and Anaphylaxis and other aspects.Product Details of 4719-04-4
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