On October 12, 2022, Kraszewski, Karol; Tomczyk, Ireneusz; Kalek, Marcin published an article.Formula: C14H22O The title of the article was Intermolecular enantioselective dearomatizing para-methoxylation of phenols using 2-iodoresorcinol/lactamide catalysts. And the article contained the following:
Intermol. enantioselective oxidative para-dearomatization of phenols with the addition of methanol, catalyzed by a chiral 2-iodoresorcinol/lactamide, was developed. The reaction allows for the synthesis of a broad range of 4-methoxy-2,5-cyclohexadienone products with up to 62% ee (from 2,4-disubstituted phenols in 43-62% ee; from a 3,4-disubstituted phenol in 17% ee; from 4-substituted-1-naphthols in 38-44% ee). Reported results constitute a proof of concept that the enantioselectivity in challenging intermol. dearomatization of phenols can be considerably improved in a simple way, namely, by increasing the steric bulk of the coupling partner upon replacing water with methanol. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Formula: C14H22O
The Article related to phenol iodoresorcinol lactamide catalyst dearomatizing enantioselective regioselective methoxylation, cyclohexadienone preparation, Alicyclic Compounds: Cyclohexanes and other aspects.Formula: C14H22O
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