On March 15, 2021, Jones, David S.; Rafferty, Gerard P.; Andrews, Gavin P. published an article.Recommanded Product: Pentane-1,5-diol The title of the article was Drug release from hydroxypropylcellulose gels cannot be statistically predicted from their viscometric and initial viscoelastic properties. And the article contained the following:
This study questioned whether rheol. properties can predict drug (metronidazole) release from Hydroxypropylcellulose (HPC) platforms. Viscometric and viscoelastic properties of aqueous, alcs./diols and mixed solvent HPC solutions and gels were determined using viscometry and oscillatory anal. Drug release was conducted at pH 7.4 under sink conditions. Relationships between rheol. parameters and drug release were modelled using multiple linear stepwise regression. Viscometry identified ethanol and water as good solvents for HPC. Diol solvents were predicted to exhibit greater interactions with HPC (COSMO modeling) but possessed lowest intrinsic viscosities. Pentanediol or ethylene glycol prepared gels exhibited greatest elasticity. No relationships were observed between dilute solution properties and initial gel viscoelasticity. Drug release from HPC gels occurred via gel erosion and diffusion. No relationships were observed between initial gel viscoelasticity and drug release and thus, for gel platforms that undergo erosion in aqueous media, drug release cannot be predicted from initial gel viscoelasticity. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Recommanded Product: Pentane-1,5-diol
The Article related to hydroxypropylcellulose gel metronidazole release viscoelasticity viscometry, drug diffusion, gel erosion, statistical modelling, viscoelasticity, viscometric properties, Pharmaceuticals: Pharmaceutics and other aspects.Recommanded Product: Pentane-1,5-diol
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