Formica, Michele; Sorin, Geoffroy; Farley, Alistair J. M.; Diaz, Jesus; Paton, Robert S.; Dixon, Darren J. published an article in 2018, the title of the article was Bifunctional iminophosphorane catalysed enantioselective sulfa-Michael addition of alkyl thiols to alkenyl benzimidazoles.Formula: C7H6F3NO And the article contains the following content:
The first enantioselective sulfa-Michael addition of alkyl thiols to alkenyl benzimidazoles, enabled by a bifunctional iminophosphorane (BIMP) organocatalyst, was described. The iminophosphorane moiety of the catalyst provided the required basicity to deprotonate the thiol nucleophile while the chiral scaffold and H-bond donor control facial selectivity. The reaction was broad in scope with respect to the thiol and benzimidazole reaction partners with the reaction proceeding in up to 98% yield and 96 : 4 er. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Formula: C7H6F3NO
The Article related to alkenyl benzimidazole alkanethiol iminophosphorane organocatalyst enantioselective sulfa michael addition, alkylthio alkyl benzimidazole preparation, Aliphatic Compounds: Ethers and Sulfides and other aspects.Formula: C7H6F3NO
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