Bu, Ting; Zhang, Ming; Lee, Sun-Hee; Cheong, Yu Eun; Park, Yukyung; Kim, Kyoung Heon; Kim, Dongwon; Kim, Sooah published an article in 2022, the title of the article was GC-TOF/MS-Based Metabolomics for Comparison of Volar and Non-Volar Skin Types.Reference of 2,3-Dihydroxypropanoic acid And the article contains the following content:
Skin has heterogenous identities on different body sites despite similar cellular compositions There are two types of skin, volar (palmoplantar) and non-volar (dorsal), which are characterized by epidermal thickness, pigmentation, and presence of hair follicles. However, the mechanisms underlying the development of these different skin types remain unclear. To investigate these, we profiled the cellular metabolites of volar and non-volar skin in mice using gas chromatog.-time-of-flight/mass spectrometry (GC-TOF/MS), and further assessed the metabolic differences between them. In total, 96 metabolites from both volar and non-volar skin of mice were identified using the BinBase database system. Metabolomics anal. revealed important differences associated with amino acid metabolism (phenylalanine, tyrosine, and tryptophan biosynthesis; aspartate and glutamate metabolism), sugar metabolism (pentose phosphate pathway), and nucleotide metabolism (pyrimidine metabolism) in volar skin. Fifty metabolites were identified as potential biomarkers differentiating the physiol. characteristics of these skin types. Of these, nine were highly increased whereas 41 were significantly decreased in volar skin compared with those in non-volar skin. Overall, these results provide valuable information for understanding the metabolic differences between volar and non-volar skin. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Reference of 2,3-Dihydroxypropanoic acid
The Article related to volar nonvolar skin metabolomics gctof ms, gc-tof/ms, metabolomic analysis, non-volar skin, volar skin, Placeholder for records without volume info and other aspects.Reference of 2,3-Dihydroxypropanoic acid
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