On June 25, 2006, Yang, Dehong; Yang, Benyong; Li, Hui published an article.Category: alcohols-buliding-blocks The title of the article was Synthesis of 2-(methyl-2-pyridinylamino)ethanol. And the article contained the following:
The title compound [i.e., 2-[methyl(2-pyridinyl)amino]ethanol] is a key intermediate in the synthesis of rosiglitazone. A reaction of 2-chloropyridine with two equivalent 2-(methylamino)ethanol gave the target compound and 2-(methylamino)ethanol hydrochloride. To enhance the reaction yield, appropriately increasing reaction temperature and changing post-treatment can shorten reaction time to 7-8 h, simplify the operation and significantly improve the yield to 95%. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Category: alcohols-buliding-blocks
The Article related to rosiglitazone methylpyridinylamino ethanol preparation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Category: alcohols-buliding-blocks
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts