On February 17, 2005, Vanotti, Ermes; D’Alessio, Roberto; Tibolla, Marcellino; Varasi, Mario; Montagnoli, Alessia; Santocanale, Corrado; Martina, Katia; Menichincheri, Maria published a patent.COA of Formula: C7H8FNO The title of the patent was Preparation of pyridylpyrrole derivatives active as kinase inhibitors. And the patent contained the following:
Pyridylpyrrole derivatives of formula I [R1 = H, amino, etc.; R2, R’2 = H, halo, etc.; further detail on R1 and R’2 is given; R3, R’3, R4, R’4 = H, alkyl, etc.; R5 = H, halo, etc.] and pharmaceutically acceptable salts thereof and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer. Thus, 2-(2-cyclopentylaminopyridin-4-yl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one was prepared from 2-(2-chloropyridin-4-yl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one and cyclopentylamine. Compounds of this invention in vitro showed IC50 values of 2 nM to 20 nM against Cdc7 kinase. The experimental process involved the reaction of 1-(3-Fluoropyridin-4-yl)ethanol(cas: 87674-15-5).COA of Formula: C7H8FNO
The Article related to pyridylpyrrole derivative preparation kinase inhibitor, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.COA of Formula: C7H8FNO
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