On May 8, 2014, Robl, Jeffrey A.; Wu, Shung C.; Yoon, David S. published a patent.Application In Synthesis of (2-Fluorophenyl)methanethiol The title of the patent was Preparation of pyridone/hydroxypyridine compounds as 11β-hydroxysteroid dehydrogenase h type I inhibitors. And the patent contained the following:
Title compounds I [A = (un)substituted 4- to 15-membered mono, bi- or tricyclic aliphatic or aromatic ring, X = halo, cyano, haloalkyl, etc.; Y = bond, (un)substituted alkylene or cycloalkyl, etc.; R1 = (un)substituted alkyl, heteroaryl, aryl, heterocyclyl, etc.; W = bond, alkyl, O, S, SO, SO2, etc.], and their enantiomers, diastereomers, solvates, salts, tautomers or prodrugs, are prepared as 11-beta-hydroxysteroid dehydrogenase type I inhibitors. Thus, e.g., II was prepared by reaction of cyclohexanone with malononitrile followed by reaction with 2-chlorobenzyl bromide. Compound II showed IC50 value of 2.95 nM at the in vitro inhibition of recombinant human 11β-HSD1 assay. The invention compounds are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy, such as diabetes, hyperglycemia, obesity, dislipidemia, hypertension, cognitive impairment, rheumatoid arthritis, osteoarthritis, glaucoma, Cushing’s disease and metabolic syndrome. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).Application In Synthesis of (2-Fluorophenyl)methanethiol
The Article related to pyridone hydroxypyridine preparation beta hydroxysteroid dehydrogenase inhibitor, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application In Synthesis of (2-Fluorophenyl)methanethiol
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