Ma, Manting; Cai, Bolin; Kong, Shaofen; Zhou, Zhen; Zhang, Jing; Zhang, Xiquan; Nie, Qinghua published an article in 2022, the title of the article was PPARGC1A Is a Moderator of Skeletal Muscle Development Regulated by miR-193b-3p.Application In Synthesis of 2,3-Dihydroxypropanoic acid And the article contains the following content:
Meat production performance is one of the most important factors in determining the economic value of poultry. Myofiber is the basic unit of skeletal muscle, and its phys. and chem. properties determine the meat quality of livestock and poultry to a certain extent. Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) as a transcriptional coactivator has been found to be widely involved in a series of biol. processes. However, PPARGC1A is still poorly understood in chickens. In this manuscript, we reported that PPARGC1A was highly expressed in slow-twitch myofibers. PPARGC1A facilitated mitochondrial biogenesis and regulated skeletal muscle metabolism by mediating the flux of glycolysis and the TCA cycle. Gain- and loss-of-function analyses revealed that PPARGC1A promoted i.m. fatty acid oxidation, drove the transformation of fast-twitch to slow-twitch myofibers, and increased chicken skeletal muscle mass. Mechanistically, the expression level of PPARGC1A is regulated by miR-193b-3p. Our findings help to understand the genetic regulation of skeletal muscle development and provide a mol. basis for further research on the antagonism of skeletal muscle development and fat deposition in chickens. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Application In Synthesis of 2,3-Dihydroxypropanoic acid
The Article related to skeletal muscle development microrna genetic regulation, ppargc1a, mir-193b-3p, mitochondrial biogenesis, muscle metabolism, skeletal muscle development, Placeholder for records without volume info and other aspects.Application In Synthesis of 2,3-Dihydroxypropanoic acid
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