On October 6, 2020, Liu, Runzeng; Mabury, Scott A. published an article.Synthetic Route of 96-76-4 The title of the article was Synthetic phenolic antioxidants: A review of environmental occurrence, fate, human exposure, and toxicity. And the article contained the following:
A review. Synthetic phenolic antioxidants (SPAs) are widely used in various industrial and com. products to retard oxidative reactions and lengthen product shelf life. In recent years, numerous studies have been conducted on the environmental occurrence, human exposure, and toxicity of SPAs. Here, we summarize the current understanding of these issues and provide recommendations for future research directions. SPAs have been detected in various environmental matrixes including indoor dust, outdoor air particulates, sea sediment, and river water. Recent studies have also observed the occurrence of SPAs, such as 2,6-di-tert-butyl-4-methylphenol (BHT) and 2,4-di-tert-butyl-phenol (DBP), in humans (fat tissues, serum, urine, breast milk, and fingernails). In addition to these parent compounds, some transformation products have also been detected both in the environment and in humans. Human exposure pathways include food intake, dust ingestion, and use of personal care products. For breastfeeding infants, breast milk may be an important exposure pathway. Toxicity studies suggest some SPAs may cause hepatic toxicity, have endocrine disrupting effects, or even be carcinogenic. The toxicity effects of some transformation products are likely worse than those of the parent compound For example, 2,6-di-tert-butyl-p-benzoquinone (BHT-Q) can cause DNA damage at low concentrations Future studies should investigate the contamination and environmental behaviors of novel high mol. weight SPAs, toxicity effects of coexposure to several SPAs, and toxicity effects on infants. Future studies should also develop novel SPAs with low toxicity and low migration ability, decreasing the potential for environmental pollution. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Synthetic Route of 96-76-4
The Article related to review synthetic phenolic antioxidants environmental occurrence human exposure toxicity, Air Pollution and Industrial Hygiene: Reviews and other aspects.Synthetic Route of 96-76-4
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