Liu, Chu; Yu, Xiangyong; Meng, Zhaorui; Zhao, Ning; Bai, Fujuan; Zhao, Longshan published an article in 2020, the title of the article was Microwave-assisted extraction (MAE) combined with gas chromatography-mass spectrometry (GC-MS) for determination of volatile small molecules to evaluate compatibility of antimicrobial peptide PL-5 spray with packaging materials.Name: 2,4-Di-tert-butylphenol And the article contains the following content:
A simple and efficient method involving microwave-assisted extraction (MAE) combined with GC-MS was established to determine 1,3-di-tert-butylbenzene (DBB), 2,4-di-tert-butylphenol (DBP), 3,5-di-tert-butyl-4-hydroxybenzaldehyde (DBHBA) for evaluating the compatibility of antimicrobial peptide PL-5 spray with drug-packaging materials. In this study, the antimicrobial peptide PL-5 spray was purified using a Welchrom C18 column, and the high-d. polyethylene spray bottle with liquid collection tube was first mixed with absolute ethanol, which would be subjected to MAE for further measurement by GC-MS. Various exptl. parameters were systematically optimized, and good linearities were obtained within the range of 0.05-1.00 μg/mL for DBB and DBHBA and 0.50-10.00 μg/mL for DBP, with limits of detection (LODs) of 0.99 ng/mL (DBB), 16.34 ng/mL (DBP), and 1.64 ng/mL (DBHBA). Satisfactory recoveries that ranged from 96.0% to 107.2% were acquired, and the relative standard deviation was ≤ 4.7%. The results showed that the maximum daily usage of DBB, DBP, and DBHBA was 9.859, 163.445, and 16.399 ng, resp., which was far below the corresponding permitted daily exposure values according to the safety assessment, indicating that the migration of analytes did not bring any potential safety risk. The compatibility between the drug and the packaging materials was favorable. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Name: 2,4-Di-tert-butylphenol
The Article related to volatile small mol antimicrobial peptide pl 5 spray, gc-ms, mae, antimicrobial peptide pl-5 spray, compatibility, volatile small molecules, Placeholder for records without volume info and other aspects.Name: 2,4-Di-tert-butylphenol
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