On October 25, 2020, Li, Xiao’Ou; Cheng, Jiahan; Shen, Yongchun; Chen, Jun; Wang, Tao; Wen, Fuqiang; Chen, Lei published an article.Application of 32462-30-9 The title of the article was Metabolomic analysis of lung cancer patients with chronic obstructive pulmonary disease using gas chromatography-mass spectrometry. And the article contained the following:
Chronic obstructive pulmonary disease (COPD), characterized by intermittent exacerbations and clin. subphenotypes like emphysema and chronic bronchitis, poses a significant risk of lung cancer (LC) development. Metabolomic studies of COPD are scarce, and those of LC patients with COPD subphenotypes have not been investigated. To study metabolite profile alteration in LC patients with different COPD subphenotypes, lung paracancer tissue from 10 LC (CON) patients, 10 LC patients with emphysema (E), and 9 LC patients with chronic bronchitis (CB) were analyzed using gas chromatog.-mass spectrometry. Multivariate anal. indicated a distinct separation between LC patients with COPD subphenotypes and LC patients. Overall, 60, 55, 33 and 63 differential metabolites (DM) were identified in comparisons between CB vs. CON, E vs. CON, CB vs. E, and CB + E vs. CON, resp., and of these, 8 DM were shared in all comparisons. Among the high altered metabolites, E samples showed higher ‘acetol’ than CON samples, and lower ‘azelaic acid’, ‘3-methylglutaric acid’ and ‘allose’. CB samples showed higher ‘turanose’ and ‘o-phosphoserine’ and lower ‘anandamide’ than CON and E samples. In CB and E samples, ‘galactonic acid’, ‘2-mercaptoethanesulfonic acid’, ‘D-alanyl-D-alanine’ ‘3-methylglutaric acid’, ‘glycine’, ‘L-4-Hydroxyphenylglycine’ and ‘O-phosphonothreonine’ had common alteration trends compared with those of CON samples. ‘Glycine’, ‘L-4-Hydroxyphenylglycine’ and ‘O-phosphonothreonine’ were significantly enriched in glycine, serine and threonine metabolism pathways. The total differential metabolites detected were remarkably altered in pyrimidine, beta-alanine and purine metabolism Our study provided altered DM patterns of lung paracancer tissue, the key metabolites and their enriched metabolic pathways in LC patients with different COPD subphenotypes. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Application of 32462-30-9
The Article related to metabolomic lung cancer obstructive disease, chronic obstructive pulmonary disease, gas chromatography-mass spectrometry, lung cancer, metabolite, Mammalian Pathological Biochemistry: Oncology and other aspects.Application of 32462-30-9
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