On March 31, 2010, Karthikeyan, K.; Balaji, T. S.; Shanmugasundaram, P.; Chandrasekara Pillai, K. published an article.Formula: C7H16O2 The title of the article was Stability-Indicating HPLC Method for the Determination of Impurities in Meprobamate with Refractive Index Detection. And the article contained the following:
The purpose of this study is to develop and validate a simple, sensitive, and robust high-performance liquid chromatog. (HPLC) method for the determination of impurities ca. 2-methyl-2-propyl-1,3-propane diol (MP0) and 2-hydroxymethyl-2-Me pentyl carbamate (MP1) in meprobamate (MEP) drug substance with refractive index (RI) detection. This method utilizes a Zorbax Eclipse XDB C18 HPLC column, a mobile phase of 80:20 (volume/volume) 10 mM KH2PO4,-acetonitrile, resp. The stability-indicating capability of the method was established by performing stress studies under acidic, basic, oxidation, light, humidity, and thermal conditions. The major degradation products of acid and base hydrolysis are identified as MP0 and MP1. The recovery data obtained for impurities are between 96.0-109.8%. The detection and quantitation limits of this method ranges from 0.009 to 0.017 mg/mL and 0.029 to 0.055 mg/mL, resp. The relative standard deviation (RSD) for the area at QL is < 6.1%. Good linearity (r2 > 0.99) and precision (RSD < 2.2%) were obtained for MEP, MP0, and MP1. This method was applied successfully to determine the content of impurities in MEP bulk drug. (c) 2010 Preston Publications. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Formula: C7H16O2
The Article related to meprobamate impurity determination rp hplc stability refractive index, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Formula: C7H16O2
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