On October 4, 2007, Hannam, Joanne Clare; Hartmann, Sascha; Madin, Andrew; Ridgill, Mark Peter published a patent.Application of 386704-04-7 The title of the patent was Preparation of piperidines and related compounds as γ-secretase modulators for treatment of diseases associated with amyloid beta deposition in the brain. And the patent contained the following:
Title compounds [I; p = 0, 1; q = 0-3; V = bond, C atom bound to H, R2, XZ; W = N, C bound to H, R2, XZ; X = bond, C(R1)2, CH2C(R1)2; Y = bond, CH2, CH2CH2; Z = CO2H, tetrazolyl; R1 = H, nonaromatic hydrocarbyl; R1R1 = atoms to form an alicyclic group; R3, R4 = H; when V, W = C, then R3R4 = CH2CH2; R5 = H, alkyl, fluoroalkyl, alkoxy, fluoroalkoxy, alkenyl; R6 = Het-A; A = bond, CH2, 1,4-phenylene; Het = (substituted) heterocyclyl; R7 = hydrocarbyl optionally bearing a CF3 group; with provisos], were prepared Thus, 6-trifluoromethylnicotinaldehyde (preparation given), 2-methyl-1-buten-3-yne, Me [2-[4-(trifluoromethyl)phenyl]piperidin-4-yl]acetate hydrochloride (preparation given), and AuBr3 were microwaved together in H2O to give 64% ester derivative, which was saponified with LiOH in THF/H2O to give 71% title compound (II). In a cell-based γ-secretase assay, I showed IC50 values for inhibition of Aβ(42) production that were at least 2-fold lower than for Aβ(40). The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Application of 386704-04-7
The Article related to piperidineacetate preparation gamma secretase modulator, heteroarylmethyl pentenynyl piperidineacetate preparation amyloid beta disease treatment, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application of 386704-04-7
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts