On December 31, 2006, Geier, Johannes; Lessmann, Holger; Becker, Detlef; Bruze, Magnus; Frosch, Peter J.; Fuchs, Thomas; Jappe, Uta; Koch, Patrick; Pfoehler, Claudia; Skudlik, Christoph published an article.Synthetic Route of 4719-04-4 The title of the article was Patch testing with components of water-based metalworking fluids: results of a multicenter study with a second series. And the article contained the following:
Background: Although many allergens in metalworking fluids (MWF) are identified, there are still some MWF components, which are not sufficiently investigated concerning their sensitizing properties. Objectives: To investigate sensitization to 10 frequently used MWF components, which are not part of the established MWF test series, in metalworkers with suspected occupational dermatitis due to MWF. Patients/Methods: Oleyl alc., myristyl alc., dimethylolurea, 4,4′-methylenebis morpholine, imazalil, 1-amino-2-propanol (monoisopropanolamine; MIPA), 2-amino-2-ethyl-1,3-propanediol (AEPD), 2,5-bis(n-octyldithio)-1,3,4-thiadiazole, zinc alkyl dithiophosphate and dibenzyl disulfide have been patch tested in 144 patients. Results: 7 patients reacted pos. to the formaldehyde releaser 4,4′-methylenebis morpholine, and 6 of these patients also reacted to formaldehyde and/or other formaldehyde releasers. 4 Patients reacted pos. to myristyl alc. tested at 10% petrolatum (pet.). Addnl., 20 doubtful or irritant reactions occurred. 1 Patient each reacted pos. to oleyl alc., MIPA, and AEPD. None of the other test substances mentioned above elicited any clear-cut pos. reaction. Patch testing with well-known MWF allergens showed proportions of pos. reactions, which were comparable to those from other studies, e.g. 11% to monoethanolamine, 8% to colophonium and 3%-5% to various preservatives. Conclusions: 4,4′-methylenebis morpholine may be an important MWF allergen, although clin. relevance could not be stated definitely in every case. Myristyl alc. should not be patch tested at 10% pet., but at a lesser concentration, due to irritant properties. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Synthetic Route of 4719-04-4
The Article related to skin allergy allergen metalworking fluid occupational health hazard, Toxicology: Chemicals (Household, Industrial, General) and other aspects.Synthetic Route of 4719-04-4
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