On August 21, 2020, Foth, Paul J.; Malig, Thomas C.; Yu, Hao; Bolduc, Trevor G.; Hein, Jason E.; Sammis, Glenn M. published an article.Synthetic Route of 143-10-2 The title of the article was Halide-Accelerated Acyl Fluoride Formation Using Sulfuryl Fluoride. And the article contained the following:
Herein, we report a new one-pot sequential method for SO2F2-mediated nucleophilic acyl substitution reactions starting from carboxylic acids. A mechanistic study revealed that SO2F2-mediated acid activation proceeds via the anhydride, which is then converted to the corresponding acyl fluoride. Tetrabutylammonium chloride or bromide accelerate the formation of acyl fluoride. Optimized halide-accelerated conditions were used to synthesize acyl fluorides in 30-80% yields, and esters, amides, and thioesters in 72-96% yields without reoptimization for each nucleophile. Safety: toxic SO2F2. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Synthetic Route of 143-10-2
The Article related to halide accelerated acyl fluoride formation sulfuryl fluoride, safety toxic sulfuryl fluoride, General Organic Chemistry: Synthetic Methods and other aspects.Synthetic Route of 143-10-2
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