On June 28, 2018, Din Belle, David; Makela, Mikko; Passiniemi, Mikko; Pietikainen, Pekka; Rummakko, Petteri; Tiainen, Eija; Vaismaa, Matti; Wohlfahrt, Gerd published a patent.Safety of 2-(Methylamino)ethan-1-ol hydrochloride The title of the patent was Preparation of the pyran derivatives as cyp11a1 (cytochrome p450 monooxygenase 11a1) inhibitors. And the patent contained the following:
The invention is related to the preparation of the pyran derivatives as cyp11a1 (cytochrome P 450 monooxygenase 11a1) inhibitors I. The invention compounds I , wherein ring B is a 4-10 membered monocyclic or bicyclic ring containing 0-4 heteroatoms independently selected form N, O or S; A is 2-tetrahydroindenyl, 2-tetrahydroisoquinolinyl, etc; L is absent, CH2, CH2CH2, etc.; R1 is hydrogen, C1-7 alkyl, C1-7 alkoxy, etc.; R2 is H, halo, OH, etc.; R3 is H, halo, NO2, etc.; R4 is H, halo, OH, etc.; R5 is H, halo, C1-7 alkyl; R23 is H or oxo; R24 is H or C1-7 alkyl; and their pharmaceutically acceptable salts are claimed. Compound I was prepared by multi-step procedure (procedure given). The compounds of formula I possess utility as cytochrome P 450 monooxygenase 11A1(CYP11A1) inhibitors. The compounds are useful as medicaments in the treatment of steroidreceptor, particularly androgen receptor,dependent diseases and conditions, such asprostate cancer. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Safety of 2-(Methylamino)ethan-1-ol hydrochloride
The Article related to preparation pyran cyp11a1 cytochrome p450 monooxygenase inhibitor, Heterocyclic Compounds (One Hetero Atom): Pyrans and other aspects.Safety of 2-(Methylamino)ethan-1-ol hydrochloride
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts