Ashcraft, Luke et al. published their patent in 2019 |CAS: 306281-86-7

The Article related to bisamide preparation sarcomere modulator, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application of 306281-86-7

On March 14, 2019, Ashcraft, Luke; Boezio, Alessandro; Butler, John; Chandra, Aroop; Chuang, Chihyuan; Collibee, Scott E.; Debenedetto, Mikkel; Dimassa, Vincent; Graceffa, Russell; Malinowski, Justin; Moebius, David; Morgan, Bradley P.; Payette, Joshua; Romero, Antonio; St. Jean, David, Jr.; Vargas, Richard; Yeoman, John; Zhang, Hanmo published a patent.Application of 306281-86-7 The title of the patent was Bisamides as cardiac sarcomere modulators and their preparation. And the patent contained the following:

The invention provides a compound of formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof. Compounds of formula I wherein Q is (un)substituted aryl, (un)substituted sulfonylpyrrolidinyl, (un)substituted 5- to 6-membered heteroaryl, etc.; X1 is N and CR2; X2, X3, X4 and X5 are independently N and CR3, provided at 0, 1 or 2 of X1 – X5 are N and the remaining are CR2 and CR3; R1a is H, C1-6 alkyl and halo; R1 is H, C1-6 alkyl, C1-6 alkenyl, C2-6 alkynyl, etc.; R2 is H, halo, C1-6 alkyl, C1-6 haloalkyl, etc.; R1R2 can be taken together to form (CH2)1-3, OCH2, CH2OCH2, etc.; R3 is H, halo, C1-6 alkyl, SF5, etc.; R13a is H and C1-6 alkyl; R13 and R14 are independently C1-6 alkyl, C3-7 cycloalkyl, and C3-7 cycloalkyl-C1-6 alkyl; R13R14 can be taken together to form (un)fused (un)saturated 4- to 7-membered heterocyclyl; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by amidation of (R)-1-((S)-1-((3-cyanoazetidin-1-yl)sulfonyl)piperidine-3-carbonyl)pyrrolidine-2-carboxylic acid with benzylamine. The invention compounds were evaluated for their cardiac sarcomere modulatory activity (some data given). The experimental process involved the reaction of (R)-2-Amino-2-(4-(trifluoromethyl)phenyl)ethanol(cas: 306281-86-7).Application of 306281-86-7

The Article related to bisamide preparation sarcomere modulator, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application of 306281-86-7

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts