On July 20, 2018, Yin, Xuguang; Huang, Yi; Chen, Ziyi; Hu, Yang; Tao, Lin; Zhao, Qingyang; Dong, Xiu-Qin; Zhang, Xumu published an article.HPLC of Formula: 280752-78-5 The title of the article was Enantioselective Access to Chiral 2-Substituted 2,3-Dihydrobenzo[1,4]dioxane Derivatives through Rh-Catalyzed Asymmetric Hydrogenation. And the article contained the following:
Rh-catalyzed asym. hydrogenation of various benzo[b][1,4]dioxine derivatives, e.g. I, was successfully developed to prepare chiral 2-substituted 2,3-dihydrobenzo[1,4]dioxane derivatives using ZhaoPhos and N-methylation of ZhaoPhos ligands with high yields and excellent enantioselectivities (up to 99% yield, >99% enantiomeric excess (ee), turnover number (TON) = 24,000). Moreover, this asym. hydrogenation methodol., as the key step with up to 10 000 TON, was successfully applied to develop highly efficient synthetic routes for the construction of some important biol. active mols., such as MKC-242, WB4101, BSF-190555 and (R)-doxazosin·HCl. The experimental process involved the reaction of (6-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol(cas: 280752-78-5).HPLC of Formula: 280752-78-5
The Article related to rhodium catalyst hydrogenation benzodioxin asym preparation, Heterocyclic Compounds (More Than One Hetero Atom): Dioxanes and other aspects.HPLC of Formula: 280752-78-5
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