On October 8, 2015, Weigel, Lena F.; Nitsche, Christoph; Graf, Dominik; Bartenschlager, Ralf; Klein, Christian D. published an article.Safety of H-Phg(4-OH)-OH The title of the article was Phenylalanine and Phenylglycine Analogues as Arginine Mimetics in Dengue Protease Inhibitors. And the article contained the following:
Dengue virus is an increasingly global pathogen. One of the promising targets for antiviral drug discovery against dengue and related flaviviruses such as West Nile virus is the viral serine protease NS2B-NS3. We here report the synthesis and in vitro characterization of potent peptidic inhibitors of dengue virus protease that incorporate phenylalanine and phenylglycine derivatives as arginine-mimicking groups with modulated basicity. The most promising compounds were (4-amidino)-L-phenylalanine-containing inhibitors, which reached nanomolar affinities against dengue virus protease. The type and position of the substituents on the phenylglycine and phenylalanine side chains has a significant effect on the inhibitory activity against dengue virus protease and selectivity against other proteases. In addition, the non-natural, basic amino acids described here may have relevance for the development of other peptidic and peptidomimetic drugs such as inhibitors of the blood clotting cascade. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Safety of H-Phg(4-OH)-OH
The Article related to phenylalanine phenylglycine based arginine mimetic tripeptide preparation antiviral, dengue protease inhibitor tripeptide arginine mimetic, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.Safety of H-Phg(4-OH)-OH
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