On April 2, 2021, Tailor, Sanita B.; Manzotti, Mattia; Smith, Gavin J.; Davis, Sean A.; Bedford, Robin B. published an article.Related Products of 78-26-2 The title of the article was Cobalt-Catalyzed Coupling of Aryl Chlorides with Aryl Boron Esters Activated by Alkoxides. And the article contained the following:
The cobalt-catalyzed Suzuki biaryl cross-coupling of aryl chloride substrates with aryl boron reagents, activated with more commonly used bases, remained a significant unmet challenge in the race to replace platinum group metal catalysts with Earth-abundant metal alternatives. This highly desirable process can be realized using alkoxide bases, provided the right counterion is employed, strict stoichiometric control of the base is maintained with respect to the aryl boron reagent, and the correct boron ester is selected. Potassium tert-butoxide works well, but any excess of the base first inhibits and then poisons the catalyst. Lithium tert-butoxide performs very poorly, while even catalytic amounts of lithium additives also poison the catalyst. Meanwhile, a neopentane diol-based boron ester is required for best performance. As well as delivering this sought-after transformation, a detailed mechanistic and computational investigations to probe the possible mechanism of the reaction has been discussed and explains the unexpected exptl. observations. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Related Products of 78-26-2
The Article related to biaryl preparation transmetalation key step kinetics linear free energy, aryl chloride boron reagent alkoxide suzuki coupling cobalt catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Others and other aspects.Related Products of 78-26-2
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts