On April 26, 1991, Shirahama, Haruhisa; Shinozaki, Atsuhiko published a patent.HPLC of Formula: 42900-89-0 The title of the patent was Preparation of pyrrolidineacetic acid derivatives as nervous system stimulants. And the patent contained the following:
The title compounds (I; R1-R3 = H, alkyl) and their stereoisomers are prepared Selective oxidation of 63 mg methanol derivative II (R = CH2OH) (preparation given) with pyridinium dichromate in DMF followed by esterification with CH2N2 gave 26 mg ester II (R = CO2Me), which (186 mg) was ring-opened by m-ClC6H4CO2OH and esterified by CH2N2 to give 48 mg diester III (R2 = R3 = Me) (IV). Saponification of 48 mg IV gave 26 mg diacid III (R2 = R3 = H), which (20 mg) was deprotected by hydrogenolysis over 5% Pd-C to give 9 mg (2β,3α,4α)-I (R1 = R2 = R3 = H). I caused significant depolarization in newborn rat spinal cord in vitro as measured by elec. potential, against such reference compounds as kainic acid and acromelic acid. The experimental process involved the reaction of Isochroman-3-ol(cas: 42900-89-0).HPLC of Formula: 42900-89-0
The Article related to pyrrolidineacetic acid preparation nervous stimulant, Heterocyclic Compounds (One Hetero Atom): Pyrroles and Pyrrolizines and other aspects.HPLC of Formula: 42900-89-0
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