On June 23, 2005, Scott, Ian L.; Ralph, Jeffrey M.; Voss, Matthew E. published a patent.Electric Literature of 72364-46-6 The title of the patent was Preparation of vinorelbine derivatives as antitumor agents. And the patent contained the following:
Vinorelbine derivatives of formula I [R1 = alkyl, aryl, heterocyclyl, halo, CN, CHO, acyl, (substituted) SH, alkylsulfonyl, etc.; R2 = alkyl, CHO; R3 = H, alkyl, acyl; R4 = H, acyl; X = alkoxy, (substituted) NH2, etc.] are prepared Pharmaceutical compositions containing these compounds as well as processes of preparation and processes of use for treatment of various conditions are also disclosed. Thus, 11′-bromovinorelbine (II) was prepared from vinorelbine tartrate. II inhibited growth of HeLa and MCF-7 cells with GI50 values of 5 nM and 3 nM, resp. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).Electric Literature of 72364-46-6
The Article related to vinorelbine derivative preparation antitumor, Alkaloids: Alkaloids Containing Three Or More Nitrogen Atoms and other aspects.Electric Literature of 72364-46-6
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