On December 31, 2020, Ma, Yibao; Wang, Wei; Devarakonda, Teja; Zhou, Huiping; Wang, Xiang-Yang; Salloum, Fadi N.; Spiegel, Sarah; Fang, Xianjun published an article.SDS of cas: 32462-30-9 The title of the article was Functional analysis of molecular and pharmacological modulators of mitochondrial fatty acid oxidation. And the article contained the following:
Abstract: Fatty acid oxidation (FAO) is a key bioenergetic pathway often dysregulated in diseases. The current knowledge on FAO regulators in mammalian cells is limited and sometimes controversial. Previous FAO analyses involve nonphysiol. culture conditions or lack adequate quantification. We herein described a convenient and quant. assay to monitor dynamic FAO activities of mammalian cells in physiol. relevant settings. The method enabled us to assess various mol. and pharmacol. modulators of the FAO pathway in established cell lines, primary cells and mice. Surprisingly, many previously proposed FAO inhibitors such as ranolazine and trimetazidine lacked FAO-interfering activity. In comparison, etomoxir at low micromolar concentrations was sufficient to saturate its target proteins and to block cellular FAO function. Oxfenicine, on the other hand, acted as a partial inhibitor of FAO. As another class of FAO inhibitors that transcriptionally repress FAO genes, antagonists of peroxisome proliferator-activated receptors (PPARs), particularly that of PPARa, significantly decreased cellular FAO activity. Our assay also had sufficient sensitivity to monitor upregulation of FAO in response to environmental glucose depletion and other energy-demanding cues. Altogether this study provided a reliable FAO assay and a clear picture of biol. properties of potential FAO modulators in the mammalian system. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).SDS of cas: 32462-30-9
The Article related to monocytic lymphoma breast carcinoma fatty acid oxidation mitochondria, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.SDS of cas: 32462-30-9
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