On December 31, 2020, Fagbohun, Oladapo F.; Oriyomi, Olumayowa V.; Adekola, Mukaila B.; Msagati, Titus A. M. published an article.Computed Properties of 96-76-4 The title of the article was Biochemical applications of Kigelia africana (Lam.) Benth. fruit extracts in diabetes mellitus. And the article contained the following:
Abstract: The use of Kigelia africana plant is beneficial in many medicinal applications. This study investigated the chem. compounds as well as antioxidant and antidiabetic activities of KA fruits in vitro and in vivo. From the result of GC-qTOF-MS, phenol-2,4-bis(1,1-dimethylethyl)-, benzene propanoic acid-3,5-bis(1,1-dimethylethyl)-4-hydroxymethylester, naphthalene-2-methyl-, and oxalic acid-4-chlorophenyl nonyl-ester were newly identified and revealed a strong binding affinity of – 6.1, – 6.3, – 6.8, and – 6.2 kcal/mol resp. The hexane and Et acetate fractions had the highest antioxidant activities with 0.14 and 0.025 mg/mL for DPPH; 91.31 and 99.20 mg AAE/g for FRAP; and 80.61 and 98.88 mg AAE/g for TPC, resp. Hexane fraction (HF) had the lowest IC50 value (1.97 mg/mL) against α-amylase. At low and middle doses, HF showed significant ameliorative activities by restoring islet cells, increasing the number of β cells, and reducing fasting blood glucose levels. Significant differences were observed in the activities of GGT and G-6-PDH. KA fruit exhibited high antidiabetic and antihyperglycemic activities in STZ-induced diabetic rats. According to mol. docking study, the use of the base structure of 2,4-ditert-butylphenol identified from K. africana fruit may serve as the novel approach to the treatment of diabetes mellitus. Graphical abstract: [graphic not available: see fulltext]. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Computed Properties of 96-76-4
The Article related to kigelia fruit extract diabetes mellitus, Food and Feed Chemistry: Fruits, Vegetables, Legumes, and Nuts and other aspects.Computed Properties of 96-76-4
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