Deidda, Martino; Noto, Antonio; Cadeddu Dessalvi, Christian; Andreini, Daniele; Andreotti, Felicita; Ferrannini, Eleuterio; Latini, Roberto; Maggioni, Aldo P.; Magnoni, Marco; Mercuro, Giuseppe; on behalf of the CAPIRE Investigators published an article in 2022, the title of the article was Why Do High-Risk Patients Develop or Not Develop Coronary Artery Disease? Metabolic Insights from the CAPIRE Study.Computed Properties of 473-81-4 And the article contains the following content:
Traditional cardiovascular (CV) risk factors (RFs) and coronary artery disease (CAD) do not always show a direct correlation. We investigated the metabolic differences in a cohort of patients with a high CV risk profile who developed, or did not develop, among those enrolled in the Coronary Atherosclerosis in Outlier Subjects: Protective and Novel Individual Risk Factors Evaluation (CAPIRE) study. We studied 112 subjects with a high CV risk profile, subdividing them according to the presence (CAD/High-RFs) or absence of CAD (No-CAD/High-RFs), assessed by computed tomog. angiog. The metabolic differences between the two groups were identified by gas chromatog.-mass spectrometry. Characteristic patterns and specific metabolites emerged for each of the two phenotypic groups: high concentrations of pyruvic acid, pipecolic acid, p-cresol, 3-aminoisobutyric acid, isoleucine, glyceric acid, lactic acid, sucrose, phosphoric acid, trimethylamine-N-oxide, 3-hydroxy-3-methylglutaric acid, erythritol, 3-hydroxybutyric acid, glucose, leucine, and glutamic acid; and low concentrations of cholesterol, hypoxanthine, glycerol-3-P, and cysteine in the CAD/High-RFs group vs the No-CAD/High-RFs group. Our results show the existence of different metabolic profiles between patients who develop CAD and those who do not, despite comparable high CV risk profiles. A specific cluster of metabolites, rather than a single marker, appears to be able to identify novel predisposing or protective mechanisms towards CAD beyond classic CVRFs. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Computed Properties of 473-81-4
The Article related to pyruvic pipecolic acid isoleucine p cresol coronary artery disease, atherosclerosis, cardiovascular risk factors, coronary artery diseases, metabolomics, Mammalian Pathological Biochemistry: Cardiovascular Diseases and other aspects.Computed Properties of 473-81-4
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