On December 31, 2021, Cagetti, Maria Grazia; Cocco, Fabio; Calzavara, Ezio; Augello, Davide; Zangpoo, Phunchok; Campus, Guglielmo published an article.Recommanded Product: 585-88-6 The title of the article was Study protocol for a randomized clinical trial to evaluate the effect of the use of Xylitol gum in the prevention of caries lesions in children living in Ladakh-the Caries Prevention Xylitol in Children (CaPreXCh) trial. And the article contained the following:
Xylitol use is reported to be able to reduce dental plaque amount and cariogenic bacteria and, as a consequence, the caries increment. Only few data on the oral health of Ladakh’s population are available. The aim of the present protocol will be to record the caries prevalence of primary and permanent molars of school children living in Ladakh and to implement a school-based Xylitol program, named the Caries Prevention Xylitol in Children (CaPreXCh) trial, using chewing gums. The protocol is designed as a triple-blind randomized, controlled, parallel-group clin. trial in children aged 5-14 years. The study should have been carried out from August 2021 to August 2024 in Zanskar Valley (Ladakh), but the COVID-19 pandemic does not allow today to make predictions on the exact start. Participants will be randomly allocated into two groups: subjects who will receive a chewing gum with Xylitol (70% w/v) as only sweetener, and those who will receive a sugared chewing gum containing Maltitol (23% w/v). The subjects will be instructed to chew a total of 6 pellets for 5 min divided into 3 intakes a day (2 in the morning, 2 after the midday meal and 2 in the afternoon) for one school year. Clin. examination will comprise an oral examination in which caries index (ICDAS scores), bleeding on probing and plaque pH evaluation after sucrose challenge will be recorded at baseline (t0); the clin. examination will be repeated after 12 mo since the beginning of the chewing gum administration period (t1), after another 12-mo period (t2) and finally after further 12 mo (t3) (24 mo from the end of the chewing gum use). The primary outcome will be the caries increment measured both at enamel and dentinal levels on primary and permanent molars. Data anal. will be conducted through Kaplan-Meyer graphs to evaluate caries increment. A comparison of the methods will be carried out with Cox regression with shared frailty. The net caries increment for initial, moderate and severe caries levels, using ICDAS (Δ-initial, Δ-moderate and Δ-severe), will be calculated This trial will be the first trial conducted in India assessing the efficacy of a school-based caries preventive program through the use of chewing gum containing only Xylitol as a sweetener. The findings could help strengthen the evidence for the efficacy of Xylitol use in community-based caries prevention programs in children. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Recommanded Product: 585-88-6
The Article related to xylitol chewing gum dental caries india, Pharmacology: Effects Of Inflammation Inhibitors and Immune Agents and other aspects.Recommanded Product: 585-88-6
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts