On February 20, 2014, Barr, Kenneth Jay; MacLean, John; Zhang, Hongjun; Beresis, Richard Thomas; Zhang, Dongshan published a patent.Product Details of 62640-03-3 The title of the patent was 3-Cyclohexenyl and cyclohexyl-substituted indole and indazole compounds as ROR-gamma-T inhibitors and their preparation. And the patent contained the following:
The invention relates to compounds of formula I, and pharmaceutically acceptable salts or solvates thereof. Such compounds can be used in the treatment of ROR-gamma-T-mediated diseases or conditions. Compounds of formula I wherein dashed bond is single and double bond; X is CH2, CO and CRb; Y is CH, CRa and N; n is 0, 1, 2, 3, and 4; A4 is CR5 and N; A5 is CR5 and N; A6 is CR6 and N; A7 is CR7 and N; with the proviso that no more than two of A4 – A7 are N; Ra and Rb are independently C1-4 alkyl; R1 is (un)substituted C3-12 carbocyclyl and (un)substituted 4- to 12-membered heterocyclyl; R2 is hydroxycarbonyl, hydroxycarbonyl-C1-10 alkyl, and carbamoyl; R3 is H, halo, CN, NO2, etc.; R4 – R7 are independently H, halo, amino, CN, OH, etc.; and pharmaceutically acceptable salts and solvates thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their RORγ-T inhibitory activity. From the assay, it was determined that compound II exhibited IC50 value of 18 nM. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Product Details of 62640-03-3
The Article related to indole indazole preparation rorgammat inhibitors, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Product Details of 62640-03-3
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