On December 8, 2011, Barnes, Michael Christopher Stratton; Flack, Stephen Sean; Fraser, Ian; Lumley, James Andrew; Pang, Pui Shan; Spencer, Keith Charles; Tiberghien, Nathalie Anne Laure; Tomkinson, Gary Peter published a patent.Safety of (6-(Trifluoromethyl)pyridin-3-yl)methanol The title of the patent was Preparation of benzodiazepine compounds useful for the treatment of hepatitis C. And the patent contained the following:
The invention concerns benzodiazepine derivatives of Formula I (L1 is O or NR8, wherein R8 is H, C1-6 alkyl, etc.; L2 is -(CR9R10)n-, wherein n = 1-6 and R9 and R10 independently are H, C1-6 alkyl, or cyclopropyl; A is aryl, a 5-6 membered monocyclic heteroaryl ring, etc.; R1 is H or fluoro; R2 is H, halo, C1-6 alkyl, etc.; R3 is H, C1-6 alkyl or halo; R4 is H, halo, C1-6 alkyl, etc.; R5 is H, halo, or C1-6 alkyl; R6 is H, halo, C1-6 alkyl, etc.; and R7 is H, C1-6 alkyl, halo, etc.; X is CH or N). The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the treatment or prophylaxis of hepatitis C virus infection. Example compound II was prepared by reacting 3-amino-5-(2,4,6-trichlorophenyl)-1,3-dihydrobenzo[e][1,4]diazepin-2-one hydrochloride and 2-(3-(2H-tetrazol-5-yl)propoxy)-5-chlorobenzoic acid. When tested in assays that measured HCV polymerase inhibitory activity and/or reduction of HCV replicon levels, all of the exemplified compounds of the invention had IC50 values < 10 μM, indicating that they are expected to possess useful therapeutic properties. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Safety of (6-(Trifluoromethyl)pyridin-3-yl)methanol
The Article related to benzodiazepine compound preparation treatment hepatitis c, Heterocyclic Compounds (More Than One Hetero Atom): Diazepines and other aspects.Safety of (6-(Trifluoromethyl)pyridin-3-yl)methanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts