Abranches, Dinis O.; Soares, Bruna P.; Ferreira, Ana M.; Shimizu, Seishi; Pinho, Simao P.; Coutinho, Joao A. P. published an article in 2022, the title of the article was The impact of size and shape in the performance of hydrotropes: a case-study of alkanediols.Related Products of 111-29-5 And the article contains the following content:
Inspired by the recently proposed cooperative mechanism of hydrotropy, where water mols. mediate the aggregation of hydrotrope around the solute, this work studies the impact of apolar volume and polar group position on the performance of hydrotropes. To do so, the ability of two different families of alkanediols (1,2-alkanediols and 1,n-alkanediols) to increase the aqueous solubility of syringic acid is initially investigated. Interestingly, it is observed that in the dilute region (low hydrotrope concentration), the relative position of the hydroxyl groups of the alkanediols does not impact their performance. Instead, their ability to increase the solubility of syringic acid correlates remarkably well with the size of their alkyl chains. However, this is not the case for larger hydrotrope concentrations, where 1,2-alkanediols are found to perform, in general, better than 1,n-alkanediols. These seemingly contradictory findings are reconciled using theor. and exptl. techniques, namely the cooperative model of hydrotropy and chem. environment probes (Kamlet-Taft and pyrene polarity scales). It is found that the number of hydrotropes aggregated around a solute mol. does not increase linearly with the apolar volume of the former, reaching a maximum instead. This maximum is discussed in terms of competing solute-hydrotrope and hydrotrope-hydrotrope interactions. The results suggest that hydrotrope self-aggregation is more prevalent in 1,n-alkanediols, which neg. impacts their performance as hydrotropes. The results reported in this work support the cooperative model of hydrotropy and, from an application perspective, show that hydrotropes should be designed taking into consideration not only their apolar volume but also their ability to stabilize their self-aggregation in water, which neg. impacts their performance as solubility enhancers. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Related Products of 111-29-5
The Article related to alkanediol solubility hydortropy simulation modeling, Physical Organic Chemistry: Other Reactions, Processes, and Spectra and other aspects.Related Products of 111-29-5
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