On January 12, 2011, Yu, Shishan; Chen, Xiaoguang; Xu, Song; Qu, Jing; Zhou, Qing; Ma, Shuanggang published a patent.Formula: C3H10ClNO The title of the patent was Cassaine alkaloid analogs, their preparation method, and medical application. And the patent contained the following:
The invention disclosed a kind of Cassaine alkaloid analogs, preparation method, and medical application as antitumor agents. The claimed Cassaine alkaloid analogs are shown in structure I and II (R1, R2 = H, (un)substituted C1-C6 alkyl, Ph, -NR1R2 forming 5-member, 6-member or 7-member heterocycle containing 1-3 heteroatoms; R = H, (un)substituted C1-C6 alkyl). The claimed compounds are prepared from III and R1NHR2 amine via amidation (detail procedure given). The obtained compound and pharmaceutical acceptable salts , hydrates, esters, etc., can be used as antitumor agents for preventing and/or treating cancer. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Formula: C3H10ClNO
The Article related to cassaine alkaloid analog synthesis amidation antitumor agent, Terpenes and Terpenoids: Diterpenes (C20), Including Gibberellins, Retinoids, Quassinoids, and Tocopherols and other aspects.Formula: C3H10ClNO
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