On March 17, 2016, Viet, Andrew Quoc; Wurtz, Nicholas R. published a patent.Recommanded Product: 72364-46-6 The title of the patent was Thioether triazolopyridine and triazolopyrimidine inhibitors of myeloperoxidase. And the patent contained the following:
The invention provides compounds of formula I as myeloperoxidase (MPO) and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments. Compounds of formula I wherein ring A is substituted Ph and (un)substituted 5-to 6-membered heteroaryl; X is CH and N; Y is substituted hydrocarbon linker and substituted hydrocarbon-heteroatom linker; R1 is CN, OH, C1-4 (halo)alkyl, etc. ; and stereoisomers, tautomers, pharmaceutically acceptable salts, polymorphs and solvates thereof, are claimed. Example compound II was prepared by thiolation of 7-chloro-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine with 1-phenylethylthiol. The invention compounds were evaluated for their myeloperoxidase and/or eosinophil peroxidase inhibitory activity. From the assay, it was determined that compound II exhibited IC50 value ranged from 0.001 μM to 0.01 μM. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).Recommanded Product: 72364-46-6
The Article related to preparation thioether triazolopyridine triazolopyrimidine inhibitor myeloperoxidase eosinophil peroxidase, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Recommanded Product: 72364-46-6
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