On June 21, 2007, Vanotti, Ermes; Forte, Barbara; Martina, Katia; Menichincheri, Maria; Cirla, Alessandra; Orsini, Paolo published a patent.HPLC of Formula: 87674-15-5 The title of the patent was Preparation of heteroarylpyrrolopyridinones active as kinase inhibitors. And the patent contained the following:
The title compounds I [A = pyridin-4-yl, 3-fluoropyridin-4-yl, 2-aminopyrimidin-4-yl; R1 = H, halo, alkyl; R2 = H, alkyl, cycloalkyl, etc.; R3-R6 = H, haloalkyl, polyfluorinated alkyl, etc.; and their pharmaceutically acceptable salts] that are effective in antagonizing activity toward Cdk2 or Cdc7, were prepared Over twenty compounds I were prepared Thus, reacting tert-Bu DL-6-(3-aminopropyl)-4-oxo-2-(pyridin-4-yl)-1,4,6,7-tetrahydropyrrolo[3,2-c]pyridine-5-carboxylate with 2-methylpropionaldehyde in the presence of sodium cyanoborohydride followed by deprotection afforded DL-6-(3-isobutylaminopropyl)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one as dihydrochloride. The experimental process involved the reaction of 1-(3-Fluoropyridin-4-yl)ethanol(cas: 87674-15-5).HPLC of Formula: 87674-15-5
The Article related to heteroarylpyrrolopyridinone preparation cdk2 cdc7 protein kinase inhibitor, heteroaryl pyrrolopyridinone preparation cdk2 cdc7 protein kinase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.HPLC of Formula: 87674-15-5
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