On October 29, 2020, Siegel, Stephan; Siegel, Franziska; Schulze, Volker; Berger, Markus; Graham, Keith; Suelzle, Detlev; Boemer, Ulf; Korr, Daniel; Schroeder, Jens; Moenning, Ursula; Niehues, Michael; Meyerson, Matthew; Greulich, Heidi; Kaplan, Bethany published a patent.Synthetic Route of 1620510-51-1 The title of the patent was Preparation of 4H-pyrrolo[3,2-c]pyridin-4-one derivatives as EGFR inhibitors. And the patent contained the following:
Title compounds I [wherein X and Y independently = O or (un)substituted NH; R1 = Me, Et, or CF3, etc.; R2 = H, Me, or Et, etc.; R3 = H or F; R4 = H or Me; R5 = H, CF3, or C1-3 alkyl, etc.; A = (HCR6)n, n is 0 or 1; R6 = H, C1-3 alkyl, or C1-3 haloalkyl], and their pharmaceutically acceptable salts thereof, were prepared as EGFR inhibitors. Thus, the invention compound I (X = Y = O; R1 = OMe; R2 = Cl; R3 = H; R4 = H; R5 = H; A = absence) was prepared and gave a mutEGFR inhibition IC50 value of 1.59E-10 mol/L in D770_N771insSVD kinase assay. The experimental process involved the reaction of (R)-(4-Methylmorpholin-3-yl)methanol(cas: 1620510-51-1).Synthetic Route of 1620510-51-1
The Article related to pyrrolopyridinone antitumor preparation egfr inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Synthetic Route of 1620510-51-1
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts