On September 29, 2017, Shen, Peng; Hu, Qingchuan; Dong, Meixue; Bai, Shunjie; Liang, Zihong; Chen, Zhi; Li, Pengfei; Hu, Zicheng; Zhong, Xiaogang; Zhu, Dan; Wang, Haiyang; Xie, Peng published an article.Reference of H-Phg(4-OH)-OH The title of the article was Venlafaxine exerts antidepressant effects possibly by activating MAPK-ERK1/2 and P13K-AKT pathways in the hippocampus. And the article contained the following:
Serotonin noradrenaline reuptake inhibitors are effective antidepressant drugs, which include venlafaxine and duloxetine. Venlafaxine is commonly used in a clin. context, but the mol. biol. mechanisms behind its effects have not been fully determined Here, we explored the potential biol. effects of venlafaxine on mouse hippocampus. Mice were randomly divided into two groups and injected daily with 0.9% NaCl solution or venlafaxine. A GC-MS-based metabolomic approach was used to identify possible metabolic differences between these groups, and the key proteins involved in the relevant pathways were validated by western blotting. In our experiments, 27 hippocampal metabolites that distinguished the venlafaxine group from the control group were identified. These differential metabolites were subjected to Ingenuity Pathway Anal., which revealed that they were strongly related to two metabolic pathways (MAPK-ERK1/2 and P13K-AKT signaling pathways). Six key proteins, BDNF, p-c-Raf, p-MAPK, p-MEK, p-AKT, and CREB, were verified by western blotting and the results were consistent with the differential metabolites identified by GC-MS. This study sheds light on the biol. mechanisms underlying the effects of venlafaxine. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Reference of H-Phg(4-OH)-OH
The Article related to venlafaxine antidepressant hippocampus mapk erk1 erk2 p13k akt, antidepressant, hippocampus, mechanism, metabolomics, venlafaxine, western blotting, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Reference of H-Phg(4-OH)-OH
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts