On February 18, 2022, Schmidt, Michael A. published an article.Reference of Isochroman-3-ol The title of the article was Effect of Terminal Alkylation of Aryl and Heteroaryl Hydrazines in the Fischer Indole Synthesis. And the article contained the following:
The effect of alkylation on the terminal position of aryl and heteroaryl hydrazines in the Fischer indole synthesis was examined Compared to their unalkylated counterparts, reactions using alkylated s provided indole products with higher yields and faster rates. The reactions can be conducted at lower temperatures and are compatible with acid-sensitive functionality. The terminally alkylated hydrazines were readily prepared by a new two-step sequence and held as stable hydrazinium salts. The mild formation of the salts along with the favorable Fischer indole reaction conditions highlights the potential of this approach in later-stage synthetic use. The experimental process involved the reaction of Isochroman-3-ol(cas: 42900-89-0).Reference of Isochroman-3-ol
The Article related to fischer indole synthesis, hydrazine ketone alkylation amidation cross coupling, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Reference of Isochroman-3-ol
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