On March 15, 2018, Sato, Takahiro; Nagayama, Yukiho; Yoshino, Yasuhiro; Inoue, Tsutomu; Kato, Hiroshige; Amata, Junichiro; Inaba, Masato; Yamoto, Noriko; Taniguchi, Tetsuya published a patent.HPLC of Formula: 386704-04-7 The title of the patent was Preparation of heterocyclic compounds having erythropoietin-production acceleration activity. And the patent contained the following:
Disclosed are compounds I [X = oxygen atom, nitrogen atom, sulfur atom, etc.; R1-R3 = independently H or alkyl; R4 = H, alkyl or aryl-alkyl; R5 = alkyl, alkenyl, alkynyl, etc. (wherein alkyl, alkenyl and alkynyl are optionally substituted with halo, methoxy, trifluoromethoxy, etc.); or pharmaceutically acceptable salts thereof] and pharmaceutical composition Thus, compound II was prepared via reaction of 2,4-dimethylbenzyl alc. with methanesulfonyl chloride followed by in-situ treatment with [(7-benzyloxy-5-mercapto[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl)amino]acetic acid tert-Bu ester and de-esterification. The invention compounds, e.g., II, promoted erythropoietin (EPO) production in Hep3B cells. Of note, compounds I are useful for the treatment of anemia. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).HPLC of Formula: 386704-04-7
The Article related to heterocycle preparation erythropoietin production promoter, antianemic agent triazolopyridine erythropoietin production acceleration, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.HPLC of Formula: 386704-04-7
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts