On August 14, 2014, Jorand-Lebrun, Catherine; Kulkarni, Santosh; Christmann-Franck, Serge published a patent.Computed Properties of 1333264-06-4 The title of the patent was Macrocyclic pyridazinone derivatives as IRAK inhibitors and their preparation. And the patent contained the following:
The invention relates to compounds of formula I, and their use in the prophylaxis and treatment of diseases. Compounds of formula I wherein R1 and R3 are independently H, (CH2)0-2CONH2 and derivatives, OH and derivatives, halo, etc.; R2 is H, (un)substituted (un)branched C1-3 alkyl; R4 is H and (un)substituted (un)branched C1-10 alkyl where one or two methylene units may be replaced with O; Z is absent, arylenediene and heterocyclenediene; L is (CH2)1-6 wherein one or two methylene units may be replaced by O and CH=CH; and their pharmaceutically usable tautomers, solvates, salts, stereoisomers, and mixtures in all ratios, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their IRAK inhibitory activity. From the assay it was determined that compound II exhibited IC50 values of < 0.1 μM towards both IRAK1 and IRAK4. The experimental process involved the reaction of [4-Fluoro-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol(cas: 1333264-06-4).Computed Properties of 1333264-06-4
The Article related to macrocyclic pyridazinone preparation irak inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Computed Properties of 1333264-06-4
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