On July 3, 2008, Ibrahim, Prabha N.; Bremer, Ryan; Zhang, Chao; Zhang, Jiazhong; Hirth, Klaus-Peter; Wu, Guoxian; Zhu, Hongyao published a patent.Recommanded Product: 386704-04-7 The title of the patent was Pyrrolo[2,3-]pyridine compounds and methods for kinase modulation, preparation, pharmaceutical compositions and use in the treatment of diseases. And the patent contained the following:
Compounds of formula I, which are active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases. Compounds of formula I wherein A1 is O, CR40R41, CO and NH and derivatives; Z2 is N and CR56; Z6 is N and CR52; L3 is NH and derivatives, S, O, CONH and derivatives, NHCO and derivatives, etc.; R40, R41, R52 and R56 are independently H, F, lower (fluoro)alkyl, lower (fluoro)alkoxy, lower (fluoro)alkylthio, etc.; R61 is H, and lower (fluoro)alkyl; R100 and R101 are independently H, OH, NH2, CN, CO2H, NO2, SO2NH2, CONH2, etc.; R53 and R55 are independently H, halo, (un)substituted lower alkyl and (un)substituted lower alkoxy; n is 0, 1, 2 and 3; and their salts, prodrugs, tautomers, and isomers thereof, are claimed. Example compound II was prepared by addition of 7-azaindole to 4-(4-chlorobenzyloxy)-3-fluorobenzaldehyde; the resulting [4-(4-chlorobenzyloxy)-3-fluorophenyl]-(1H-pyrrolo[2,3-b]pyridin-3-yl)methanol underwent oxidation to give compound II. All the invention compounds were evaluated for their protein kinase modulatory activity (some data given). The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Recommanded Product: 386704-04-7
The Article related to pyrrolopyridine preparation protein kinase modulator treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Recommanded Product: 386704-04-7
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