On July 3, 2008, Ibrahim, Prabha N.; Bremer, Ryan; Zhang, Chao; Zhang, Jiazhong; Hirth, Klaus-Peter; Wu, Guoxian; Zhu, Hongyao published a patent.Application of 386704-04-7 The title of the patent was Pyrrolo[2,3-b]pyridine compounds and methods for kinase modulation, preparation, pharmaceutical compositions and use in the treatment of diseases. And the patent contained the following:
Compounds of formula I, which are active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases. Compounds of formula I wherein n is 0, 1, 2 and 3; Z2 is N and CR12; Z6 is CR16; L4 is (CR10R11)p-X-(CR10R11)q; X is O, S, NH and derivatives, CO, CS, SO, SO2, CONH and derivatives, CSNH and derivatives, NHCO and derivatives, etc.; p and q are independently 0, 1 and 2, provides that at least one of p and 1 is 0; R4, R5, R6, R11, R15, R16 and R60 is H, halo, (un)substituted lower alkyl, (un)substituted lower alkenyl, (un)substituted lower alkynyl, (un)substituted (hetero)cycloalkyl, (un)substituted (hetero)aryl, etc.; R61 is H and lower (fluoro)alkyl; A is O, S, CH2, CHOH, CHNH2, CF2, CHF, NH and derivatives, CO, CS, SO, SO2, etc.; R10 and R11 and independently H, F and (un)substituted lower alkyl; R17 is H, halo, (un)substituted lower alkyl, OH and derivatives; and their salts, prodrugs, tautomers and isomers thereof, are claimed. Example compound II was prepared by benzylation of 4-hydroxy-3-methoxybenzaldehyde with 4-chlorobenzyl bromide; the resulting 4-(4-chlorobenzyloxy)-3-methoxybenzaldehyde underwent addition of 7-azaindole to give 3-((4-(4-chlorobenzyloxy)-3-methoxyphenyl)(methoxy)methyl)-1H-pyrrolo[2,3-b]pyridine, which underwent demethoxylation to give compound II. All the invention compounds were evaluated for their protein kinase modulatory activity (some data given). The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Application of 386704-04-7
The Article related to pyrrolopyridine preparation protein kinase modulator treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Application of 386704-04-7
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