On November 23, 2017, Gao, Peng; Xiu, Wenhua; Wang, Shaobao; Liu, Lei; Bao, Rudi published a patent.Category: alcohols-buliding-blocks The title of the patent was FGFR4 inhibitor, preparation method and applications. And the patent contained the following:
The invention disclosed a kind of FGFR4 inhibitor, its preparation method and application. The claimed FGFR4 inhibitor is shown in structure I (X1 = -(CR3R4)m1-; X2 = -(CR5R6)m2-; X3 = -(CR7R8)m3-; Y = O or S; Z = NX4, O or S; X4 = H, C1-8 alkyl or haloalkyl, C3-8 cycloalkyl; R = H, halo, hydroxy, mercapto, cyano, etc.; R1 = H, halo, hydroxy, mercapto, cyano, nitro, C3-8 cycloalkyl, heterocyclo, etc.; R2 = halo, hydroxy, mercapto, cyano, nitro, etc.; R3,R4,R5,R6,R7,R8 = H, D, halo, C1-8 alkyl, C2-8 alkenyl, alkynyl, etc.). The claimed compound is prepared via multiple steps (procedure given). The prepared compound have a very-strong inhibition effect on the activity of FGFR4 kinase, has very-high selectivity, can be widely used in the preparation of drugs for treating cancers, specially liver cancer, stomach cancer, prostate cancer, skin cancer, ovarian cancer, lung cancer, breast cancer or colon cancer, and can be developed into a rnew-generation FGFR4 inhibitor drug. The experimental process involved the reaction of 1-[(Dibenzylamino)methyl]cyclopropanol(cas: 428855-17-8).Category: alcohols-buliding-blocks
The Article related to fgfr4 inhibitor preparation antitumor agent, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Category: alcohols-buliding-blocks
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts