On January 11, 2017, Duan, Wenhu; Geng, Meiyu; Yan, Wei; Ding, Jian; Ai, Jing; Zhao, Bin; Fan, Jun; Peng, Xia; Chen, Yi published a patent.Electric Literature of 87674-15-5 The title of the patent was Preparation of 3-(heteroaryl)indazole derivatives useful as FGFR1 inhibitor for the treatment of cancer. And the patent contained the following:
The invention relates to 3-(heteroaryl)indazole derivatives of formula I, method for their preparation and their use as FGFR1 inhibitor for the treatment of cancer. Compounds of formula I, wherein R1, R2, R3 are independently H and halo; R9 is (un)substituted 5- to 7-membered heteroaryl; R8 and R10 are independently H, halo, C1-3alkyl and C1-3alkoxy; R4, R5, R6 and R7 are independently H, halo, (un)substituted C1-8alkyl, etc.; M is CH2, CH, N, O and S; W is O and NH; dotted bond is single or double bond and can not be same, are claimed. Example compound II was prepared via a multistep procedure (procedure given). All the invention compounds were evaluated for their FGFR1 inhibitory activity. From the assay, it was determined that example compound II exhibited IC50 value of < 10 nM towards FGFR1. The experimental process involved the reaction of 1-(3-Fluoropyridin-4-yl)ethanol(cas: 87674-15-5).Electric Literature of 87674-15-5
The Article related to heteroarylindazole preparation fgfr1 inhibitor treatment cancer, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Electric Literature of 87674-15-5
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