On June 24, 2004, Corbett, Jeffrey Wayne; Groppi, Vincent Edward, Jr. published a patent.Name: (6-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol The title of the patent was A preparation of azabicycloalkane derivatives, useful as α7 nicotinic acetylcholine receptor (α7 nAChR) agonists. And the patent contained the following:
The invention relates to azabicycloalkane derivatives of formula azabicyclo-N(R1)-C(:X)-W [wherein: R1 is H, (cyclo)alkyl, or haloalkyl, etc.; X is O or S; W is a substituted benzene], useful as α7 nAChR agonists. Pharmacokinetics of the prepared compounds were evaluated (no biol. data). Blood-brain barrier penetration was investigated (no biol. data). For instance, chiral azabicycloheptane derivative I was prepared via addition of Me 3-bromopropargylate to N-Boc-pyrrole, reduction of the obtained azabicyclo[2.2.1]heptadiene II, hydrolysis of the obtained azabicycloheptane derivative III (R2 = OMe), reaction of the carboxylic acid III (R2 = OH) with diphenylphosphoryl azide and benzyl alc., resolution of the obtained exo-derivative IV, and hydrogenation. The experimental process involved the reaction of (6-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol(cas: 280752-78-5).Name: (6-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol
The Article related to azabicycloalkane preparation alpha7 nachr agonist nicotinic acetylcholine receptor antialzheimer, pyrrole bromo propargylate addition reduction resolution, Alicyclic Compounds: Bicyclic Compounds, Including Azulenes, Heptalenes, and Pentalenes and other aspects.Name: (6-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts