On December 3, 2020, Castro, Alfredo C. published a patent.Application of 386704-04-7 The title of the patent was Sulfamides as TEAD inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancer. And the patent contained the following:
The invention provides sulfamide compounds I, compositions thereof, and methods of using the same. Compounds of formula I wherein L1 is (un)substituted (un)branched C1-6 alkylene, etc.; ring A is Ph, (un)substituted 5- to 6-membered heteroaryl, etc.; R2 is H, (un)substituted 4- to 6-membered heteroaryl, etc.; R4 is H, halo, -SO2NH2 and derivatives, -CONH2 and derivatives; R6 is H, (un)substituted C1-6 alkyl, etc.; and their pharmaceutically acceptable salts as TEAD inhibitors in the treatment of cancer thereof, are claimed. Example compound II was prepared by using etherification and cross-coupling as the key steps. All the invention compounds were evaluated for their TEAD inhibitory activity. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Application of 386704-04-7
The Article related to sulfamide preparation tead inhibitor treatment cancer, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application of 386704-04-7
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