On March 31, 2016, Cai, Jiaqiang; Colandrea, Vincent; Crespo, Alejandro; Debenham, John; Du, Xiaoxing; Guiadeen, Deodialsingh; Liu, Ping; Liu, Rongqiang; Madsen-Duggan, Cristina B.; McCoy, Joshua G.; Quan, Weiguo; Sinz, Christopher; Wang, Liping published a patent.Safety of (6-(Trifluoromethyl)pyridin-3-yl)methanol The title of the patent was Quinolinecarboxamidoacetic acids and related compounds as inhibitors of HIF prolyl hydroxylase and their preparation. And the patent contained the following:
The invention concerns compounds of formula I or pharmaceutically acceptable salts thereof, which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier. Compounds of formula I wherein W and Z are independently CH2 and NH and derivatives; X and Y are independently CH2, O, CO and NH and derivatives; provided that when W and Z are CH2, then WZ may be taken together with another carbon to form a bridge; R1 is H, C1-4 alkyl, (un)substituted C3-8 cycloalkyl, (un)substituted aryl, (un)substituted heterocyclyl, etc.; R2 is H and Me; R3 and R4 are independently H, OH and (un)substituted C1-4 alkyl; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their HIF prolyl hydroxylase inhibitory activity. From the assay, it was determined that compound II exhibited IC50 value of 19.2 nM. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Safety of (6-(Trifluoromethyl)pyridin-3-yl)methanol
The Article related to quinolinecarboxamidoacetic acid preparation hif prolyl hydroxylase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Safety of (6-(Trifluoromethyl)pyridin-3-yl)methanol
Referemce:
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Alcohols – Chemistry LibreTexts