On March 12, 2020, Becker, Christopher; Li, Xiaolin; Lu, Peichao; Rajapaksa, Naomi Samadara; Tully, David Charles; Wang, Xiaojing Michael; Zhao, Qian published a patent.Recommanded Product: 1-[(Dibenzylamino)methyl]cyclopropanol The title of the patent was Preparation of pyridopyrazinedione compounds as antiviral agents for treating particularly herpes viruses. And the patent contained the following:
The invention is related to the preparation of compounds I [Cy = (un)substituted Ph, pyridinyl, pyrimidinyl, or a 5-8 membered cycloalkyl; R1, R2 = independently H, C1-3 alkyl; or R1CR2 = 3-6 membered cycloalkyl ring; R3 = 0-2 optional substituents on the ring to which -L-W is directly attached; R4 = H, halo, C1-3 alkyl; R5 = H, halo, CN, C1-3 alkoxy, etc.; L = C1-C4 straight chain or branched alkylene linker, or L = C1-C4 straight chain or branched alkylene linker or a bond when W is an optionally substituted ring; W = H, OH, an optionally substituted ring selected from 3-6 membered cycloalkyl, Ph, 5-6-membered heterocyclyl containing one or two N, O or S heteroatoms as ring members, and 5-membered heteroaryl containing up to 4 heteroatoms selected from N, O and S as ring members that is optionally fused to Ph, etc.; Y = (CH2)0-2] their pharmaceutically acceptable salts, to pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by herpesviruses. Thus, II (m.p. = 186°) was prepared by reaction of Bu 1,6-dioxo-2,3,4,6-tetrahydro-1H-pyrido[1,2-a]pyrazine-7-carboxylate (preparation given) with [1-(cyclopropylsulfonyl)cyclopropyl]methyl Methanesulfonate (preparation given) in DMF in the presence of NaH, acidulation of III•Na, activation of the acid III with oxalyl chloride, amidation with 4-(aminomethyl)benzonitrile hydrochloride. The exemplified compounds of the invention were studied in an CMV polymerase, CMV-luciferase and HSV polymerase assays (some data given). The activity of I against human herpes viruses CMV HSV-1, VZV and EBV was evaluated [Ec50 values of 24(±7) nM, 32(±12), 20(±8) and 12(±), resp]. The experimental process involved the reaction of 1-[(Dibenzylamino)methyl]cyclopropanol(cas: 428855-17-8).Recommanded Product: 1-[(Dibenzylamino)methyl]cyclopropanol
The Article related to pyridopyrazinedione preparation herpes antiviral, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Recommanded Product: 1-[(Dibenzylamino)methyl]cyclopropanol
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