Zhang, Ziyan; Wu, Xiaojin; Zhou, Meng; Qi, Jiaqian; Zhang, Rui; Li, Xueqian; Wang, Chang; Ruan, Changgeng; Han, Yue published an article in 2022, the title of the article was Plasma metabolomics identifies the dysregulated metabolic profile of primary immune thrombocytopenia (ITP) based on GC-MS.Computed Properties of 473-81-4 And the article contains the following content:
ITP is a common autoimmune bleeding disorder with elusive pathogenesis. Author study was implemented to profile the plasma metabolic alterations of patients diagnosed with ITP, aiming at exploring the potential novel biomarkers and partial mechanism of ITP. The metabolomic anal. of plasma samples was conducted using GC-MS on 98 ITP patients and 30 healthy controls (HCs). Age and gender matched samples were selected to enter the training set or test set resp. OPLS-DA, t-test with FDR correction and ROC analyses were employed to screen out and evaluate the differential metabolites. Possible pathways were enriched based on metabolomics pathway anal. (MetPA). A total of 85 metabolites were investigated in author’s study and 17 differential metabolites with diagnostic potential were identified between ITP patients and HCs. MetPA showed that the metabolic disorders of ITP patients were mainly related to phenylalanine, tyrosine and tryptophan biosynthesis, phenylalanine metabolism and glyoxylate and dicarboxylate metabolism Addnl., author discriminated 6 differential metabolites and 5 enriched pathways in predicting the resistance to glucocorticoids in chronic ITP patients. The distinct metabolites discovered in author’s study could become novel biomarkers for the auxiliary diagnosis and prognosis prediction of ITP. Besides, the dysregulated pathways might contribute to the development of ITP. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Computed Properties of 473-81-4
The Article related to metabolome immune thrombocytopenia gcms, opls -da, gas chromatography tandem mass spectrometry, metabolomics, metabolomics pathway analysis, primary immune thrombocytopenia and other aspects.Computed Properties of 473-81-4
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