On November 13, 1985, Schultz, Rose Ann; White, Banita D.; Dishong, Dennis M.; Arnold, Kristin A.; Gokel, George W. published an article.Computed Properties of 2160-93-2 The title of the article was 12-, 15-, and 18-Membered-ring nitrogen-pivot lariat ethers: syntheses, properties, and sodium and ammonium cation binding properties. And the article contained the following:
N-pivot lariat ethers of varying ring sizes can be prepared by cyclization of an amine or substituted diol. 12-Membered ethers I [R = PhCH2, 2-, 4-MeOC6H4, 2-MeOC6H4CH2, HO(CH2)3, Me2NCH2CH2, MeOCH2CH2; n = 1] were prepared by the method of M. Calverley and J. Dale (1982); this involves cyclo-bis-dialkylation of an amine with 1,11-diiodo-3,6,9-trioxaundecane. I (R = 2-O2NC6H4CH2, 3,6-dioxaheptyl, 3,6,9-trioxadecyl, 3,6,9,12-tetraoxatridecyl, 11-allyloxy-3,6,9-trioxaundecyl; n = 1) did not form in high yield by this method or were more conveniently prepared by alkylation of I (R = H, n = 1). The latter was prepared from I (R = PhCH2, n = 1) by hydrogenolysis. Monoaza-15-crown-5 derivatives I (R = allyl, Bu, Me3C, PhCH2, MeOCH2CH2, 3,6-dioxaheptyl, 3,6,9,12,15,18,21,24-octaoxapentacosyl, 2-MeOC6H4, 4-MeOC6H4, 2-MeOC6H4CH2; n = 2) were prepared by cyclizing RN(CH2CH2OH)2 with R1(OCH2CH2)3OR1 (R1 = MeSO2, 4-MeC6H4SO2). I (R = Me, 2-O2NC6H4CH2, 4-O2NC6H4CH2, Me3CO2CCH2, n =2) were prepared by the alkylation of I (R = H, n = 2) which was prepared by hydrogenolysis I (R = PhCH2, n = 2). Monoaza-18-crown-6 derivatives I (R = H, Me, PhCH2, MeOCH2CH2, 3,6-dioxaheptyl, 3,6,9-trioxadecyl, 3,6,9,12-tetraoxatridecyl, 3,6,9,12,15-pentaoxahexadecyl, 3,6,9,12,15,18,21,24-octaoxapentacosyl, 2-MeOC6H4; n = 3) were analogously prepared Studies involving NH4 cation binding show that the interaction of ring and side-chain with the cation is intramol. in MeOH solution; the Na cation binds similarly. X-ray crystal structure evidence confirms this for the solid state in the I (R = 2-MeOCH2CH2, n = 3)·KI complex. The strongest binding for Na occurs when 6 O are present, regardless of ring size, which suggests that a flexible macrocycle is directed by the cation to envelop and solvate in the geometry most appropriate for the cation. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Computed Properties of 2160-93-2
The Article related to azacrown ether cation binding preparation, nitrogen pivot lariat ether cation binding, crown ether cation binding preparation, inclusion compound monoazacrown ether cation, diethanolamine cyclization glycol dimesylate and other aspects.Computed Properties of 2160-93-2
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