On March 15, 2010, Reddy, M. V. Ramana; Pallela, Venkat R.; Cosenza, Stephen C.; Mallireddigari, Muralidhar R.; Patti, Revathi; Bonagura, Marie; Truongcao, May; Akula, Balaiah; Jatiani, Shashidhar S.; Reddy, E. Premkumar published an article.Category: alcohols-buliding-blocks The title of the article was Design, synthesis and evaluation of (E)-α-benzylthio chalcones as novel inhibitors of BCR-ABL kinase. And the article contained the following:
(E)-α-benzylthio and α-benzylsulfonyl chalcones such as I, an (E)-α-benzylsulfinyl chalcone, and an (E)-arylthiochalcone are prepared as inhibitors of the BCR-ABL kinase for potential use as antitumor agents; some of the chalcones act as inhibitors of BCR-ABL phosphorylation in leukemic K562 cells, known to express high levels of BCR-ABL, and in some cases show comparable cancer cell inhibition to the antitumor agent imatinib. The chalcones are prepared in two or three steps from α-bromoacetophenones, aryl or benzyl thiols, and aryl aldehydes by substitution of the α-bromoacetophenones with thiols followed by stereoselective aldol condensation of the benzylthioacetophenones with aryl aldehydes (with oxidation occurring, if necessary, before aldol condensation). Data for the inhibition of human leukemia and prostate cancer cells by approx. 500 related chalcones is provided. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).Category: alcohols-buliding-blocks
The Article related to benzylthio benzylsulfinyl benzylsulfonyl chalcone stereoselective preparation kinase inhibitor, inhibition bcr abl kinase structure benzylthio benzylsulfinyl benzylsulfonyl chalcone, antitumor activity benzylthio benzylsulfinyl benzylsulfonyl chalcone and other aspects.Category: alcohols-buliding-blocks
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts